Endocrine Abstracts

Introduction: Prostate cancer (PCa) progression is known to depend on various hormones and growth factors, but their role and underlying molecular mechanisms remain poorly understood. We recently presented preliminary findings indicating that leptin causes a greater level of activation of the JAK2/STAT3 and MAPK (ERK1/2) pathways, as well as transactivation of HER2, in androgen-sensitive LNCaP cells than in androgen-insensitive PC3 and DU145 human PCa cell lines. We and others...